Addressing the Rise of Metabolic Dysfunction-Associated Steatotic Liver Disease: How Deerwood Family Practice Can Help
The rapid increase in obesity and metabolic syndrome across the U.S. is raising serious concerns about a condition known as Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease (NAFLD). This liver condition, which is not related to alcohol consumption, often presents with no symptoms in its early stages. As MASLD advances, it can lead to Metabolic Dysfunction-Associated Steatohepatitis (MASH), where harmful fat accumulates in the liver, potentially progressing to severe outcomes like fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) if left untreated. With an estimated 100 million Americans currently living with MASLD and about 6.6 million at risk of developing liver fibrosis, it’s alarming to note that fewer than 5% of MASLD cases are accurately diagnosed. Early detection and management are crucial to prevent severe liver damage and improve patient outcomes. At Deerwood Family Practice, we are committed to advancing liver health through innovative diagnostics. We are proud to offer the OWLiver® panel, a cutting-edge, non-invasive test designed to assess the stages of MASLD with precision. Unlike traditional tests that focus solely on abnormal liver enzymes, the OWLiver® panel evaluates 28 different liver metabolites and biomarkers. This comprehensive approach provides detailed insights into the amount of fat, level of inflammation, and extent of fibrosis in the liver. The results include the MASEF Score, a highly specific, metabolomics-driven indicator that helps identify individuals at risk for MASH. Based on your unique results, we provide a range of tailored interventions to support liver health and promote natural detoxification. Our team is continually updating our knowledge through advanced education seminars on fatty liver disease to better serve our patients. Sources: Barr J, Caballería J, Martínez-Arranz I, Domínguez-Díez A, Alonso C, Muntané J, Pérez-Cormenzana M, García-Monzón C, Mayo R, Martín-Duce A, Romero-Gómez M, Lo Iacono O, Tordjman J, Andrade RJ, Pérez-Carreras M, Le Marchand-Brustel Y, Tran A, Fernández-Escalante C, Arévalo E, García-Unzueta M, Clement K, Crespo J, Gual P, Gómez-Fleitas M, Martínez-Chantar ML, Castro A, Lu SC, Vázquez-Chantada M, Mato JM. Obesity-dependent metabolic signatures associated with nonalcoholic fatty liver disease progression. J Proteome Res. 2012 Apr 6;11(4):2521-32. doi: 10.1021/pr201223p. Epub 2012 Mar 15. PMID: 22364559; PMCID: PMC3321123. Mayo R, Crespo J, Martínez-Arranz I, Banales JM, Arias M, Mincholé I, Aller de la Fuente R, Jimenez-Agüero R, Alonso C, de Luis DA, Vitek L, Stritesky J, Caballería J, Romero-Gómez M, Martín-Duce A, Mugüerza Huguet JM, Busteros-Moraza JI, Idowu MO, Castro A, Martínez-Chantar ML, Ortiz P, Bruha R, Lu SC, Bedossa P, Noureddin M, Sanyal AJ, Mato JM. Metabolomic-based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts. Hepatol Commun. 2018 May 4;2(7):807-820. doi: 10.1002/hep4.1188. PMID: 30027139; PMCID: PMC6049064. . Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-1835. doi: 10.1097/ HEP.0000000000000323 Bril F, McPhaul MJ, Kalavalapalli S, et al. Intact fasting insulin identifies nonalcoholic fatty liver disease in patients without diabetes. J Clin Endocrinol Metab. 2021;106(11):4360-e4371. doi: 10.1210/clinem/dgab417 Sarkar M, Yates K, Suzuki A, et al. Low testosterone is associated with nonalcoholic steatohepatitis and fibrosis severity in men. Clin Gastroenterol Hepatol. 2021;19(2):400-402.2. doi: 10.1016/j.cgh.2019.11.053 Kizivat T, Maric I, Mudri D, Curcic IB, Primorac D, Smolic M. Hypothyroidism and nonalcoholic fatty liver disease: pathophysiological associations and therapeutic implications. J Clin Transl Hepatol. 2020;8(3):347- 353. doi: 10.14218/JCTH.2020.00027
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Are you considering supplements to enhance your overall health but unsure where to start? At Deerwood Family Practice, we recommend multivitamins as an excellent place to begin.
The Dietary Guidelines for Americans 2020-2025 highlight that many people may not get enough micronutrients from their diets alone. Factors like mass food production, food storage practices, poor dietary choices, and nutrient-depleting cooking methods can contribute to these deficiencies. While it's ideal to obtain your nutrients from a diverse diet rich in vegetables, fruits, whole grains, and dairy, sometimes this isn't enough. In such cases, high-quality multivitamin/mineral supplements can be a valuable addition to your health regimen. The products we offer at Deerwood are provided in bioactive forms so they are adequately absorbed and utilized efficiently ActivNutrients by Xymogen is a multivitamin that features a well-balanced nutrient profile, including calcium, magnesium, zinc, copper, vitamins C and E, bioactive folate, vitamin B12, a B vitamin complex, beta-carotene, and trace elements. The formulation is expertly balanced to enhance nutrient synergy and prevent competitive absorption issues. Additionally, it provides broad-spectrum antioxidant activity, supporting intra- and extracellular functions, and offers significant levels of bioavailable riboflavin, niacin, folate, and B12 to aid cellular detoxification and tissue support. Another option is ActivNutrients® Phyto. This premium formula combines metabolically active B vitamins and a bioavailable mineral complex for superior nutrient utilization. Alongside foundational nutrition, it includes powerful phytochemical sources such as astaxanthin and extracts from green coffee beans, green tea, and rosemary. These components work together to support antioxidant defenses, and cell protection, and help mitigate oxidative stress. Sources: 1. Block G, Jensen CD, Norkus EP, et al. Nutr J. 2007;6:30. doi:10.1186/1475-2891-6- 30 2. U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2020-2025. 9th ed. December 2020. https://www.dietaryguidelines.gov/sites/default/files/2020-12/Dietary_Guidelines_for_ Americans_2020-2025.pdf 3.Blumberg JB, Bailey RL, Sesso HD, et al. Nutrients. 2018;10(2):248. doi:10.3390/ nu10020248 4.Reider CA, Chung RY, Devarshi PP, et al. Nutrients. 2020;12(6):1735. doi:10.3390/ nu12061735 5. Multivitamin/Mineral Supplements Fact Sheet. National Institutes of Health. Updated October 12, 2021. Accessed November 29, 2021. https://ods.od.nih.gov/factsheets/ MVMS-HealthProfessional/?print=1 6.Blumberg JB, Frei BB, Fulgoni VL, et al. Nutrients. 2017;9(8):849. doi:10.3390/ nu9080849 7.Blumberg JB, Cena H, Barr SI, et al. Clin Ther. 2018;40(4):640-657. doi:10.1016/j. clinthera.2018.02.014 8. Marra MV, Bailey RL. Position of the Academy of Nutrition and Dietetics: micronutrient supplementation. J Acad Nutr Diet. 2018;118(11):2162-2173. doi:10.1016/j. jand.2018.07.022 9. Jayedi A, Rashidy-Pour A, Parohan M, et al. Adv Nutr. 2018;1;9(6):701-716. doi:10.1093/advances/nmy040 10.Doyle ME, Pariza MW. In: Kotsonis FN, Mackey MA, eds. Nutritional Toxicology. 2nd ed. Taylor & Francis; 2002:1 30. https://doi.org/10.1201/9781420025088 |
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